On the 23rd of January, we presented our recent work about the transcription factor ETV6 related inherited thrombocytopenia at the Dutch Hematology Congress.
In this new study, we confirmed the dominant negative function of the missense ETV6 variant, ETV6R369W, in megakaryocyte and platelet generation. Our findings contribute to the understanding of the underlying molecular mechanisms in thrombocytopenia caused by inherited ETV6 mutations, and potential diagnosis and treatment for these patients.
More information can be found HERE.
By Huan Zhang (PhD WP11)