WP 3, 4 (diagnostics) and WP 10, 11 and 12 (fundamental)
PhD students from WP3, 4, 10, 11 and 12 gave an update on their projects. For WP3, CAT assay and flow models have been setup for diagnostics. For WP4, inclusions will soon start at ErasmusMC for TiNkids study. For WP10, proteomic signatures of the coagulation cascade has successfully been identified by peptidomics. WP11 has set up different cellular models, including patient derived iPSCs, to study megakaryopoiesis. For WP12, patients are included for BOEC-MK study and endothelial colony forming cells (ECFCs) will be isolated and investigated in the in vitro bleeding model.
Both breakout rooms came to the conclusion that information should be shared and made clear to all work packages, which is a shared responsibility between the WP. In line with that, PhD student meetings will be set up between all groups within theme diagnostics and fundamental research every two weeks. This will likely happen in the near future. Within this meeting, PhD students will provide updates on their project and gather the available clinical and biomedical data of patients from different study centers. This will fortify the links between the different WP and centers within SYMPHONY and provide a fertile ground, based on acquired knowledge within the WP, to the success of the research within and between the WP.