Evidence for capped dosing of desmopressin in Von Willebrand disease: Quantification of the relationship between desmopressin plasma concentration and Von Willebrand factor activity by simulations
The last couple of months we have been working on quantification of the relationship between desmopressin plasma concentration and Von Willebrand factor activity within the SYMPHONY consortium / workpackage 6 (OPTI-CLOT and To WiN studies). Desmopressin is the treatment of choice for the prevention and treatment of bleeding in patients with Von Willebrand disease. [...]